Tbet -> SOCS1 STAT1 -> SOCS1 IL21R -> STAT3 IL6R -> STAT3 IL23R -> STAT3 IL12 -> STAT4 GATA3 -| STAT4 IL12R -> STAT4 STAT5 -> GATA3 GATA3 -> GATA3 Tbet -| GATA3 STAT6 -> GATA3 RORgt -| GATA3 NFAT -> GATA3 Foxp3 -| GATA3 TGFb -| GATA3 STAT3 -> IL17 STAT5 -| IL17 IL17 -> IL17 IL23R -> IL17 RORgt -> IL17 STAT1 -| IL17 NFAT -> TGFbR TGFb -> TGFbR IL6 -> IL6R IL6_e -> IL6R IL12 -> IL18R STAT6 -| IL18R IL18 -> IL18R IL21R -> RORgt STAT3 -> RORgt GATA3 -| RORgt Tbet -| RORgt IL6R -> RORgt TGFbR -> RORgt Foxp3 -| RORgt Foxp3 -| NFkB IRAK -> NFkB GATA3 -> IL4 NFAT -> IL4 STAT1 -| IL4 IL12 -| Tbet Tbet -> Tbet STAT4 -> Tbet RORgt -| Tbet Foxp3 -| Tbet STAT1 -> Tbet IFNg -| Tbet NFkB -> IL2 Tbet -| IL2 NFAT -> IL2 NFkB -> IFNg STAT3 -| IFNg Tbet -> IFNg STAT4 -> IFNg STAT6 -| IFNg NFAT -> IFNg IL21R -| Foxp3 STAT3 -> Foxp3 STAT5 -> Foxp3 GATA3 -| Foxp3 IL6R -| Foxp3 TGFbR -> Foxp3 RORgt -> IL6 IL12 -> IL12R TCR -> IL12R GATA3 -| IL12R Tbet -> IL12R STAT4 -> IL12R NFAT -> IL12R STAT3 -> IL21 NFAT -> IL21 IL2 -> IL2R NFAT -> IL2R IL2R -> STAT5 IL27 -> STAT1 Jak1 -> STAT1 NFAT -> STAT1 SOCS1 -| Jak1 IFNgR -> Jak1 TCR -> NFAT Foxp3 -| NFAT IL23 -> IL23R STAT3 -> IL23R Tbet -| IL23R IL21 -> IL21R SOCS1 -| IL4R IL4 -> IL4R IL4_e -> IL4R IL18R -> IRAK IL4R -> STAT6 SOCS1 -| STAT6 IFNg -| STAT6 IFNg_e -> IFNgR NFAT -> IFNgR IFNg -> IFNgR $Foxp3: ((TGFbR & !(((IL6R & STAT3) | GATA3) | IL21R)) | (STAT5 & !(((IL6R & STAT3) | GATA3) | IL21R))) $GATA3: ((((STAT6 & NFAT) & !(((TGFb | Tbet) | RORgt) | Foxp3)) | (GATA3 & !Tbet)) | (STAT5 & !(((TGFb | Tbet) | RORgt) | Foxp3))) $IFNg: ((((STAT4 & (NFkB & NFAT)) & !(STAT6 | STAT3)) | NFkB) | (Tbet & !STAT3)) $IFNgR: ((IFNg & NFAT) | (IFNg_e & NFAT)) $IL12R: ((((STAT4 & !GATA3) | Tbet) | (IL12 & NFAT)) | (TCR & !GATA3)) $IL17: (((STAT3 & (IL17 & IL23R)) & !(STAT1 | STAT5)) | (RORgt & !STAT1)) $IL18R: ((IL18 & IL12) & !STAT6) $IL2: ((NFAT & NFkB) & !Tbet) $IL21: (STAT3 & NFAT) $IL21R: IL21 $IL23R: (STAT3 | ((IL23 & STAT3) & !Tbet)) $IL2R: (IL2 & NFAT) $IL4: ((GATA3 & NFAT) & !STAT1) $IL4R: (IL4_e | (IL4 & !SOCS1)) $IL6: RORgt $IL6R: (IL6_e | IL6) $IRAK: IL18R $Jak1: (IFNgR & !SOCS1) $NFAT: (TCR & !Foxp3) $NFkB: (IRAK & !Foxp3) $RORgt: ((TGFbR & ((STAT3 & IL6R) | (IL21R & STAT3))) & !((GATA3 | Foxp3) | Tbet)) $SOCS1: (STAT1 | Tbet) $STAT1: ((IL27 & NFAT) | Jak1) $STAT3: ((IL23R | IL21R) | IL6R) $STAT4: ((IL12R & IL12) & !GATA3) $STAT5: IL2R $STAT6: (IL4R & !(IFNg | SOCS1)) $TGFbR: (TGFb & NFAT) $Tbet: ((((Tbet & (!IL12 & !IFNg)) & !(Foxp3 | RORgt)) | (STAT1 & !(Foxp3 | RORgt))) | (STAT4 & !(Foxp3 | RORgt)))